Association between glycosylated hemoglobin A1C and non-renal complications in patients with diabetes mellitus A single-center observational study.

Abstract

Association between glycosylated hemoglobin A1C and non-renal complications in patients with diabetes mellitus: A single-center observational study.

Abstract

Introduction: Diabetes is one of the most emblematic public health problems worldwide; a high level of HbA1c represents an important risk factor for the development of cardiovascular and renal disease, among other conditions. Objectives. To establish non-renal complications in diabetic patients admitted to a public reference hospital in Guayaquil, Ecuador.

Methods: This is a descriptive, prospective, correlational, and cross-sectional study, which included 103 individuals admitted to the Teodoro Maldonado Carbo Hospital who met the inclusion criteria between March and September 2022.

Results: The main acute complications were infections, 32%, followed by EHH, 27.5%. Coronary artery disease, followed by peripheral vascular disease, stands out among the chronic complications. Most patients concomitantly present 2 or more complications more frequently than 1 isolated one (36% men, 27% women). Upon hospital admission, it is evident that 75.6% of the cases had HbAc1 values above 7.6%; a 1% increase in HbA1c was associated with a 30% increase in all-cause mortality and a 40% increase in ischemic heart disease.

Conclusions: There is a positive correlation between HbAc1 and non-renal complications in diabetics, with a Pearson coefficient of 0.91% for acute and chronic complications.