Aggressive giant cell tumor bone A case report and review of the literature.

Abstract

Introduction: Giant cell tumor of bone is a pathology formed by the proliferation of multinucleated giant cells of the osteoclast type mixed with mononuclear cells of benign behavior. It can present locally aggressively and with a tendency to local recurrence. This review aims to describe two surgical clinical cases of giant cell tumors with aggressive behavior and individualized treatment.

Cases: We present two cases of highly aggressive giant cell tumors located in the distal radius and proximal tibia, and the results were compared with the literature. The age ranged from 40 to 70 years, and male and female sex was recorded.

Discussion: Giant cell tumors are locally aggressive benign neoplasms that can affect the local and surrounding bone structure. The standard treatment is surgery. The therapeutic options will depend on the degree of involvement.

Conclusion: GCTs of bone comprise approximately 3% and 5% of primary bone tumors; their behavior is benign but can present locally aggressively. The standard treatment is surgery.