Association between histopathological results of prostate biopsies guided by US-MRI fusion images and systematic ultrasound biopsies for the diagnosis of prostate cancer A multicenter observational study.

Abstract

Introduction: The importance of making an early diagnosis of prostate cancer determines the prognosis and survival of patients. This study aimed to determine the associations between histopathological findings and two diagnostic methods for prostate cancer biopsy.

Methods: The present observational study was conducted at the Hospital Naval and Hospital Alcívar in Guayaquil from 2018 to 2023. Patients with a suspected diagnosis of prostate cancer who required transrectal biopsy guided by ultrasound or by US-MRI fusion images were included. The variables were age, PSA level, prostate volume, lesion location, PIRADS 3, PIRADS 4, PIRADS 5, and histopathological diagnosis.

Results: Forty-three patients underwent US-MRI biopsy, and 28 underwent ultrasound biopsy. Patients aged between 60 and 70 were included. In the US-MRI group, 25 patients (58.14%) had positive histology, and in the ultrasound biopsy group, 15 patients (53.57%) had positive histology (OR = 1.2037 [0.4616-3.1390], P = 0.7046). A higher percentage of patients classified as PI-RADS 4 or 5 had cancer, constituting 34% (n=24) of the total patients.

Conclusions: This study found a more significant association between prostate cancer and PI-RADS 4 and 5. The results of this diagnostic method were combined with those of directed and systematic techniques.